Gender Difference in Cisplatin-Induced Nephrotoxicity in a Rat Model

gender difference in cisplatin-induced nephrotoxicity in a rat model

Gender Difference in Cisplatin-Induced Nephrotoxicity in a Rat Model

BACKGROUND Nephrotoxicity and hepatotoxicity are side effects of Cisplatin (CP) therapy. OBJECTIVES We investigated the role of gender in CP-induced nephrotoxicity and hepatotoxicity. MATERIALS AND METHODS Low dose of CP (1 mg/kg/day; ip) was administered daily to male and female Wistar rats for 15 consecutive days. Serum creatinine (Cr), blood urea nitrogen (BUN), malondialdehyde (MDA), ni...

gender difference in cisplatin-induced nephrotoxicity in a rat model: greater intensity of damage in male than female

background nephrotoxicity and hepatotoxicity are side effects of cisplatin (cp) therapy. objectives we investigated the role of gender in cp-induced nephrotoxicity and hepatotoxicity. materials and methods low dose of cp (1 mg/kg/day; ip) was administered daily to male and female wistar rats for 15 consecutive days. serum creatinine (cr), blood urea nitrogen (bun), malondialdehyde (mda), nitric...

Hydrogen sulfide ameliorates the kidney dysfunction and damage in cisplatin-induced nephrotoxicity in rat

Hydrogen Sulfide (H2S) prevents and treats a variety of disorders via its cytoprotective effects. However, the effects of H2S on rats with cisplatin (CP) nephrotoxicity are unclear. The aim was to study the effects of H2S on rats with CP nephrotoxicity. Thirty male Sprague-Dawley rats were divided into three groups: control group, nephrotoxic group received sing...

Effect of Simvastatin on Cisplatin-induced Nephrotoxicity in Male Rats

      Statins have antioxidant and anti-inflammatory effects that are not directly related to their cholesterol-lowering activity. This study aimed to investigate the effect of simvastatin on the extent of tissue damage in cisplatin-induced nephrotoxicity. Simvastatin was orally given to rats in different doses (1, 2 and 4 mg/kg), 1 h prior to cisplatin injection (5 mg/kg, i.p.). All animals we...